Human Meibum and Tear Film Derived (O-acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics

Abstract

Meibomian gland dysfunction (MGD) produces alterations in the tear film (TF) lipid layer that causes excessive evaporation of tears from the ocular surface and subsequent increased osmolarity leading to dry eye disease. However, the molecular mechanism underlying TF evaporation has yet to be understood. This study aimed to investigate the association between (o-acyl)-omega-hydroxy fatty acids (OAHFAs) derived from TF and meibum and TF evaporation in a cohort of healthy and MGD subjects.

Date
May 1, 2021 1:00 PM — May 27, 2021 2:00 PM
Dr Safal Khanal
Dr Safal Khanal
Assistant Professor

Dr. Safal Khanal is an Assistant Professor at the University of Alabama at Birmingham School of Optometry. He studies dry eye pathogenesis, emmetropisation, eye growth regulation, and refractive development.

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