Dry eye

Human Meibum and Tear Film Derived (O-acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics

Meibomian gland dysfunction (MGD) produces alterations in the tear film (TF) lipid layer that causes excessive evaporation of tears from the ocular surface and subsequent increased osmolarity leading to dry eye disease. However, the molecular …

The role of (O-acyl)-Omega-Hydroxy Fatty Acids in Human Lipid Layer Structure and Function in Health and Meibomian Gland Dysfunction (PI, Jason Nichols)

This project aims to investigate the role of (O-acyl)-Omega-Hydroxy Fatty Acids in alterations of human tear film lipid layer as a basis for formulating novel therapeutics for meibomian gland dysfunction.